Department of Anatomy, Inje University
MENU

Kim Yeong Seok


김영석 (Kim Yeong Seok) 교수 Professor
의학박사 (MD., PhD.)

2005년 인제의대 발령

♦ 강의분야 : 해부학, 조직학, 발생학, 신경해부학, 법의학
♦ 연구분야 : 종양면역, Exosome 세포상호작용, miRNA

 

[연구논문]

  1. Kim D, Hur DY, Kim YS, Lee K, Lee Y, Cho D, Kang JS, Kim YI, Hahm E, Yang Y, Yoon S, Kim S, Lee WB, Park HY, Kim YB, Hwang YI, Chang KY, Lee WJ. CM1 ligation initiates apoptosis in a caspase 8-dependent manner in Ramos cells and in a mitochondria-controlled manner in Raji cells. Hum Immunol. 2002 Jul;63(7):576-87.
  2. Cho D, Hahm E, Kang JS, Kim YI, Yang Y, Park JH, Kim D, Kim S, Kim YS, Hur D, Park H, Pang S, Hwang YI, Lee WJ. Vitamin C downregulates interleukin-18 production by increasing reactive oxygen intermediate and mitogen-activated protein kinase signalling in B16F10 murine melanoma cells. Melanoma Res. 2003 Dec;13(6):549-54.
  3. Cho D, Kim YI, Kang JS, Hahm E, Yang Y, Kim D, Kim S, Kim YS, Hur D, Park H, Hwang YI, Kim TS, Lee WJ. Resistance to cytotoxic chemotherapy is induced by NK cells in non-Hodgkin’s Lymphoma Cells. J Clin Immunol. 2004 Sep;24(5):553-60.
  4. Kang JS, Cho D, Kim YI, Hahm E, Kim YS, Jin SN, Kim HN, Kim D, Hur D, Park H, Hwang YI, Lee WJ. Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down-regulation of transferrin receptor dependent iron uptake. J Cell Physiol. 2005 Jul;204(1):192-7.
  5. Lee YS, Kim YS, Kim D, Hur DY, Kang JS, Kim YI, Hahm E, Cho D, Hwang YI, Lee WJ. CM1 Ligation Induces Apoptosis via Fas-FasL Interaction in Ramos Cells, but via Down-regulation of Bcl-2 and Subsequent Decrease of Mitochondrial Membrane Potentialin Raji Cells. Immune Netw. 2006 Dec;6(2):59-66.
  6. Kim YS, Park GB, Choi YM, Kwon OS, Song HK, Kang JS, Kim YI, Lee WJ, Hur DY. Ligation of centrocyte/centroblast marker 1 on Epstein-Barr virus–transformed B lymphocytes induces cell death in a reactive oxygen species–dependent manner. Hum Immunol. 2006 Oct;67(10):795-807. Epub 2006 Aug 11.
  7. Kang JS, Kim HN, Jung da J, Kim JE, Mun GH, Kim YS, Cho D, Shin DH, Hwang YI, Lee WJ. Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membrane. J Invest Dermatol. 2007 Mar;127(3):698-706. Epub 2006 Sep 28.
  8. Hahm E, Jin DH, Kang JS, Kim YI, Hong SW, Lee SK, Kim HN, Jung DJ, Kim JE, Shin DH, Hwang YI, Kim YS, Hur DY, Yang Y, Cho D, Lee MS, Lee WJ. The molecular mechanisms of vitamin C on cell cycle regulation in B16F10 murine melanoma. J Cell Biochem. 2007 Apr 23; 102:1002-10.
  9. Kim YS, Park GB, Song HK, Hur I, Lee HK, Kang JS, Hahm E, Lee WJ, Hur DY. Cross-linking of CD54 on Burkitt Lymphoma Cell Line Raji and Ramos Induces FasL Expression by Reactive Oxygen Species and Apoptosis of Adjacent Cells in Fas/FasL Interaction. J Immunother (1997). 2007 Oct;30(7):727-739.
  10. Song H, Park G, Kim YS, Hur I, Kim H, Ryu JW, Lee HK, Cho DH, Choi IH, Lee WJ, Hur DY. B7-H4 reverse signaling induces the apoptosis of EBV-transformed B cells through Fas ligand up-regulation. Cancer Lett. 2008 Apr 14; 266(2):227-237.
  11. Kim YS, Park GB, Lee HK, Song H, Choi IH, Lee WJ, Hur DY. Cross-linking of B7-H1 on EBV-transformed B cells induces apoptosis through reactive oxygen species production, JNK signaling activation, and fasL expression. J Immunol. 2008 Nov 1;181(9):6158-69.
  12. Park GB, Song H, Kim YS, Sung M, Ryu JW, Lee HK, Cho DH, Kim D, Lee WJ, Hur DY. Cell cycle arrest induced by engagement of B7-H4 on Epstein?Barr virus-positive B-cell lymphoma cell lines. Immunology. 2009 Nov;128(3):360-8.
  13. Kang JS, Bae SY, Kim HR, Kim YS, Kim DJ, Cho BJ, Yang HK, Hwang YI, Kim KJ, Park HS, Hwang DH, Cho DJ, Lee WJ. Interleukin-18 increases metastasis and immune escape of stomach cancer via the downregulation of CD70 and maintenance of CD44. Carcinogenesis. 2009 Dec;30(12):1987-96.
  14. Hyunkeun Song, Indo Hur, Hyun-jin Park, Joohyung Nam, Ga Bin Park, Kyoung Hye Kong, Young Mi Hwang, Yeong Seok Kim, Dae Ho Cho, Wang Jae Lee and Dae Young Hur. Selenium Inhibits Metastasis of Murine Melanoma Cells through the Induction of Cell Cycle Arrest and Cell Death. Immune Netw. 2009 Dec;9(6):236-42.
  15. Park GB, Kim YS, Lee HK, Song H, Cho DH, Lee WJ, Hur DY. Endoplasmic Reticulum Stress-Mediated Apoptosis of EBV-Transformed B Cells by Cross-Linking of CD70 Is Dependent upon Generation of Reactive Oxygen Species and Activation of p38 MAPK and JNK Pathway. J Immunol. 2010 Dec 15;185(12):7274-84. Epub 2010 Nov 15.
  16. Song H, Park H, Kim J, Park G, Kim YS, Kim SM, Kim D, Seo SK, Lee HK, Cho D, Hur D. IDO metabolite produced by EBV-transformed B cells inhibits surface expression of NKG2D in NK cells via the c-Jun N-terminal kinase (JNK) pathway. Immunol Lett. 2011 May;136(2):187-93. Epub 2011 Jan 26.
  17. Song H, Park H, Kim YS, Kim KD, Lee HK, Cho DH, Yang JW, Hur DY. l-Kynurenine-induced apoptosis in human NK cells is mediated by reactive oxygen species. Int Immunopharmacol. 2011 Aug;11(8):932-8. Epub 2011 Feb 23
  18. Song H, Kim J, Lee HK, Park HJ, Nam J, Park GB, Kim YS, Cho D, Hur DY. Selenium inhibits migration of murine melanoma cells via down-modulation of IL-18 expression. Int Immunopharmacol. 2011 Dec;11(12):2208-13. Epub 2011 Oct 18.
  19. Park GB, Kim YS, Lee HK, Song H, Kim S, Cho DH, Hur DY. Reactive oxygen species and p38 MAPK regulate Bax translocation and calcium redistribution in salubrinal-induced apoptosis of EBV-transformed B cells. Cancer Lett. 2011 Dec 27;313(2):235-48. Epub 2011 Sep 17.
  20. Park GB, Kim YS, Song H, Kim S, Park DM, Lee WJ, Hur DY. Cross-linking of CD80 and CD86 Diminishes Expression of CD54 on EBV-transformed B Cells through Inactivation of RhoA and Ras. Immune Netw. 2011 Dec;11(6):390-398.
  21. Lee HK, Park GB, Kim YS, Song H, Broaddus VC, Hur DY. Ligation of CM1 enhances apoptosis of lung cancer cells through different mechanisms in conformity with EGFR mutation. Int J Oncol. 2013 Feb;42(2):469-77. doi: 10.3892/ijo.2012.1731. Epub 2012 Dec 7
  22. Park GB, Choi Y, Kim YS, Lee HK, Kim D, Hur DY. ROS and ERK1/2-mediated caspase-9 activation increases XAF1 expression in dexamethasone-induced apoptosis of EBV-transformed B cells. Int J Oncol. 2013 Jul;43(1):29-38. doi: 10.3892/ijo.2013.1949. Epub 2013 May 20.
  23. Park GB, Kim YS, Lee HK, Cho DH, Kim D, Hur DY. CD80 (B7.1) and CD86 (B7.2) induce EBV-transformed B cell apoptosis through the Fas/FasL pathway. Int J Oncol. 2013 Nov;43(5):1531-40. doi: 10.3892/ijo.2013.2091. Epub 2013 Sep 5.
  24. Park GB, Kim YS, Kim D, Kim S, Lee HK, Cho DH, Lee WJ, Hur DY. Melphalan-Induced Apoptosis of EBV-Transformed B Cells through Upregulation of TAp73 and XAF1 and Nuclear Import of XPA. J Immunol. 2013 Dec 15;191(12):6281-91. doi: 10.4049/jimmunol.1203442. Epub 2013 Nov 18.
  25. Park GB, Choi Y, Kim YS, Lee HK, Kim D, Hur DY. ROS-mediated JNK/p38-MAPK activation regulates Bax translocation in Sorafenib-induced apoptosis of EBV-transformed B cells. Int J Oncol. 2014 Mar;44(3):977-85. doi: 10.3892/ijo.2014.2252. Epub 2014 Jan 9.
  26. Park GB, Kim DJ, Kim YS, Kim S, Lee HK, Yang JW, Hur DY. The Epstein-Barr virus causes epithelial-mesenchymal transition in human corneal epithelial cells via Syk/Src and Akt/Erk signaling pathways. Invest Ophthalmol Vis Sci. 2014 Mar 20;55(3):1770-9. doi: 10.1167/iovs.13-12988.
  27. Kim JE, Jang MJ, Jin DH, Chung YH, Choi BS, Park GB, Kim YS, Kim S, Hur DY, Hung CF, Kim D. Paclitaxel-exposed ovarian cancer cells induce cancer?specific CD4+ T cells after doxorubicin exposure through regulation of MyD88 expression. Int J Oncol. 2014 May;44(5):1716-26. doi: 10.3892/ijo.2014.2308. Epub 2014 Feb 21.
  28. Kim JE, Lee JI, Jin DH, Lee WJ, Park GB, Kim S, Kim YS, Wu TC, Hur DY, Kim D. Sequential treatment of HPV E6 and E7-expressing TC-1 cells with bortezomib and celecoxib promotes apoptosis through p-p38 MAPK-mediated downregulation of cyclin D1 and CDK2. Oncol Rep. 2014 May;31(5):2429-37. doi: 10.3892/or.2014.3082. Epub 2014 Mar 12.
  29. Park GB, Kim D, Yoon HS, Kim YS, Lee HK, Kim KT, Jeong DH, Hur DY. Antibody ligation of CM1 on cisplatin-exposed HeLa cells induces apoptosis through reactive oxygen species-dependent Fas ligand expression. Int J Oncol. 2014 Jun;44(6):2016-24. doi: 10.3892/ijo.2014.2361. Epub 2014 Mar 27.
  30. Song H, Park H, Park G, Kim YS, Lee HK, Jin DH, Kang HS, Cho DH, Hur D. Corticotropin-releasing factor induces immune escape of cervical cancer cells by downregulation of NKG2D. Oncol Rep. 2014 Jul;32(1):425-30. doi: 10.3892/or.2014.3191. Epub 2014 May 16.
  31. Park GB, Choi Y, Kim YS, Lee HK, Kim D, Hur DY. Silencing of PKCη induces cycle arrest of EBV+ B lymphoma cells by upregulating expression of p38-MAPK/TAp73/GADD45α and increases susceptibility to chemotherapeutic agents. Cancer Lett. 2014 Aug 1;350(1-2):5-14. doi: 10.1016/j.canlet.2014.04.020. Epub 2014 Apr 28
  32. Park GB, Bang SR, Lee HK, Kim D, Kim S, Kim JK, Kim YS, Hur DY. Ligation of CD47 Induces G1 Arrest in EBV-transformed B Cells Through ROS Generation, p38 MAPK/JNK Activation, and Tap73 Upregulation. J Immunother. 2014 July/August;37(6):309-320.
  33. Yoon C, Kim D, Kim S, Park GB, Hur DY, Yang JW, Park SG, Kim YS. MiR-9 regulates the post-transcriptional level of VEGF165a by targeting SRPK-1 in ARPE-19 cells. Graefes Arch Clin Exp Ophthalmol. 2014 Jul 10; /2014 Sep;252(9):1369-1376.
  34. Park GB, Kim DJ, Kim YS, Lee HK, Kim CW, Hur DY. Silencing of galectin-3 represses osteosarcoma cell migration and invasion through inhibition of FAK/Src/Lyn activation and β-catenin expression and increases susceptibility to chemotherapeutic agents. Int J Oncol. 2015 Jan;46(1):185-94.
  35. Park GB, Hur DY, Kim YS, Lee HK, Yang JW, Kim D. TLR3/TRIF signalling pathway regulates IL-32 and IFN-β secretion through activation of RIP-1 and TRAF in the human cornea. J Cell Mol Med. 2015 May;19(5):1042-54. doi: 10.1111/jcmm.12495. Epub 2015 Mar 6.
  36. Yoon C, Kim J, Park G, Kim S, Kim D, Hur DY, Kim B, Kim YS. Delivery of miR-155 to retinal pigment epithelial cells mediated by Burkitt’s lymphoma exosomes. Tumour Biol. 2016 Jan;37(1):313-21. doi: 10.1007/s13277-015-3769-4. Epub 2015 Jul 26.
  37. Park GB, Kim D, Kim YS, Kim JW, Sun H, Roh KH, Yang JW, Hur DY. Regulation of ADAM10 and ADAM17 by Sorafenib Inhibits Epithelial-to-Mesenchymal Transition in Epstein-Barr Virus-Infected Retinal Pigment Epithelial Cells. Invest Ophthalmol Vis Sci. 2015 Aug 1;56(9):5162-73
  38. Song H, Kim Y, Park G, Kim YS, Kim S, Lee HK, Chung WY, Park SJ, Han SY, Cho D, Hur D. Transforming growth factor-β1 regulates human renal proximal tubular epithelial cell susceptibility to natural killer cells via modulation of the NKG2D ligands. Int J Mol Med. 2015 Oct;36(4):1180-1188.
  39. Moon JH, Shin JS, Hong SW, Jung SA, Hwang IY, Kim JH, Choi EK, Ha SH, Kim JS, Kim KM, Hong DW, Kim D, Kim YS, Kim JE, Kim KP, Hong YS, Choi EK, Lee JS, Hattersley M, Jin DH, Kim TW. A novel small-molecule IAP antagonist, AZD5582, draws Mcl-1 down-regulation for induction of apoptosis through targeting of cIAP1 and XIAP in human pancreatic cancer. Oncotarget. 2015 Sep 29;6(29):26895-908.
  40. Park GB, Kim D, Park SJ, Lee HK, Kim JH, Kim YS, Park SG, Choi IH, Yoon SH, Lee YJ, Paeng S, Hur DY. Pre-stimulation of CD81 expression by resting B cells increases proliferation following EBV infection, but the overexpression of CD81 induces the apoptosis of EBV-transformed B cells. Int J Mol Med. 2015 Dec;36(6):1464-78
  41. Park GB, Kim YS, Lee HK, Yang JW, Kim D, Hur DY. ASK1/JNK-mediated TAp63 activation controls the cell survival signal of baicalein-treated EBV-transformed B cells. Mol Cell Biochem. 2016 Jan;412(1-2):247-58. doi: 10.1007/s11010-015-2631-8. Epub 2015 Dec 22.
  42. Park GB, Park SH, Kim D, Kim YS, Yoon SH, Hur DY. Berberine induces mitochondrial apoptosis of EBV-transformed B cells through p53-mediated regulation of XAF1 and GADD45α. Int J Oncol. 2016 Jul;49(1):411-21. doi: 10.3892/ijo.2016.3502. Epub 2016 Apr 26
  43. Kim JE, Shin JS, Moon JH, Hong SW, Jung DJ, Kim JH, Hwang IY, Shin YJ, Gong EY, Lee DH, Kim SM, Lee EY, Kim YS, Kim D, Hur D, Kim TW, Kim KP, Jin DH, Lee WJ. Foxp3 is a key downstream regulator of p53-mediated cellular senescence. Oncogene. 2017 Jan 12;36(2):219-230. doi: 10.1038/onc.2016.193.
  44. Hong SW, Park NS, Noh MH, Shim JA, Ahn BN, Kim YS, Kim D, Lee HK, Hur DY. Combination treatment with erlotinib and ampelopsin overcomes erlotinib resistance in NSCLC cells via the Nox2-ROS-Bim pathway. Lung Cancer. 2017 Apr;106:115-124. doi: 10.1016/j.lungcan.2017.02.009.
  45. Kim D, Ko HS, Park GB, Hur DY, Kim YS, Yang JW. Vandetanib and ADAM inhibitors synergistically attenuate the pathological migration of EBV-infected retinal pigment epithelial cells by regulating the VEGF-mediated MAPK pathway. Exp Ther Med. 2017 Apr;13(4):1415-1425. doi: 10.3892/etm.2017.4110.
  46. Hong SW, Kim SM, Jin DH, Kim YS, Hur DY. RPS27a enhances EBV-encoded LMP1-mediated proliferation and invasion by stabilizing of LMP1. Biochem Biophys Res Commun. 2017 Sep 16;491(2):303-309. doi: 10.1016/j.bbrc.2017.07.105. Epub 2017 Jul 20.
  47. Choi EK, Kim SM, Hong SW, Moon JH, Shin JS, Kim JH, Hwang IY, Jung SA, Lee DH, Lee EY, Lee S, Kim H, Kim D, Kim YS, Choi YK, Kim HI, Choi HS, Cho SG, Kim JE, Kim KP, Hong YS, Lee WK, Lee JS, Kim TW, Ko SG, Jin DH. SH003 selectively induces p73-dependent apoptosis in triple negative breast cancer cells. Mol Med Rep. 2016 Oct;14(4):3955-60. doi: 10.3892/mmr.2016.5722. Epub 2016 Sep 6.
  48. Kim B, Kim J, Kim YS. Celecoxib induces cell death on non-small cell lung cancer cells through endoplasmic reticulum stress. Anat Cell Biol. 2017 Dec;50(4):293-300. doi: 10.5115/acb.2017.50.4.293
  49. Lee EY, Gong EY, Shin JS, Moon JH, Shim HJ, Kim SM, Lee S, Jeong J, Gong JH, Kim MJ, Lee DH, Park YS, Shin J, Hong SW, Kim YS, Jin DH. Human breast cancer cells display different sensitivities to ABT-263 based on the level of survivin. Toxicol In Vitro. 2018 Feb;46:229-236. doi: 10.1016/j.tiv.2017.09.023. Epub 2017 Sep 23.
  50. Kim J, Hong SW, Kim S, Kim D, Hur DY, Jin DH, Kim B, Kim YS. Cyclooxygenase-2 expression is induced by celecoxib treatment in lung cancer cells and is transferred to neighbor cells via exosomes. Int J Oncol. 2018 Feb;52(2):613-620. doi: 10.3892/ijo.2017.4227
  51. Kim D, Ahn BN, Kim Y, Hur DY, Yang JW, Park GB, Jang JE, Lee EJ, Kwon MJ, Kim TN, Kim MK, Park JH, Rhee BD, Lee SH. High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and Pioglitazone. J Diabetes Res. 2019 Jan 9;2019:2376512. doi: 10.1155/2019/2376512. eCollection 2019.
  52. Yun SM, Kim YS, Hur DY. LMP1 and 2A Induce the Expression of Nrf2 Through Akt Signaling Pathway in Epstein-Barr Virus-Transformed B Cells. Transl Oncol. 2019 Mar 22;12(5):775-783. doi: 10.1016/j.tranon.2019.02.009.
  53. Yun SM, Kim YS, Kim KH, Hur DY. Ampelopsin Induces DR5-Mediated Apoptotic Cell Death in EBV-Infected Cells through the p38 Pathway. Nutr Cancer. 2020;72(3):489-494. doi: 10.1080/01635581.2019.1639778. Epub 2019 Jul 15.
  54. Hong SW, Noh MH, Kim YS, Jin DH, Moon SH, Yang JW, Hur DY. APX-115A, a pan-NADPH Oxidase Inhibitor, Induces Caspase-dependent Cell Death by Suppressing NOX4-ROS Signaling in EBV-infected Retinal Epithelial Cells. Curr Eye Res. 2020 Sep;45(9):1136-1143. doi: 10.1080/02713683.2020.1718164. Epub 2020 Feb 4.
  55. Kim J, Noh MH, Hur DY, Kim B, Kim YS, Lee HK. Celecoxib upregulates ULBP-1 expression in lung cancer cells via the JNK/PI3K signaling pathway and increases susceptibility to natural killer cell cytotoxicity. Oncol Lett. 2020 Dec;20(6):279. doi: 10.3892/ol.2020.12142. Epub 2020 Sep 23.
  56. Lee HK, Noh MH, Hong SW, Kim SM, Kim SH, Kim YS, BroaddusVC, Hur DY. Erlotinib Activates Different Cell Death Pathways in EGFR-mutant Lung Cancer Cells Grown in 3D Versus 2D Culture Systems. Anticancer Research March 2021, 41 (3) 1261-1269; DOI: https://doi.org/10.21873/anticanres.14883
  57. Rajbongshi L, Noh MH, Kim YS, Hur DY. Effects of Epstein-Barr Virus Infection on the Response of Human Breast Cancer Cells to Nicotine. Anticancer Res. 2021 Jul;41(7):3449-3458. doi: 10.21873/anticanres.15132.
  58. Suk-Hwan Jang, Kyung-Whan Kim, Hyo Seok Jang, Yeong-Seok Kim, Hojin Kim, Youngbok Kim. Topographical measurement of the attachments of the central band of the interosseous membrane on interosseous crests of the radius and ulna. Clin Shoulder Elbow. 2021;24(4):253-260. Published online December 1, 2021 DOI: https://doi.org/10.5397/cise.2021.00451
  59. Moon SH, Park NS, Noh MH, Kim YS, Cheong SH, Hur DY. Olaparib-induced Apoptosis Through EBNA1-ATR-p38 MAPK Signaling Pathway in Epstein-Barr Virus-positive Gastric Cancer Cells. Anticancer Res. 2022 Jan;42(1):555-563. doi: 10.21873/anticanres.15513.
  60. Chung EJ, Cho HJ, Jang W, Hur DY, Kim YS, Lee KH, Kim SJ. A Case of Pathologically Confirmed Corticobasal Degeneration Initially Presenting as Progressive Supranuclear Palsy Syndrome. J Korean Med Sci. 2022 Jun 6;37(22):e183. doi: 10.3346/jkms.2022.37.e183.
  61. Chung EJ, Cho HJ, Hur DY, Kim YS, Lee KH, Kim SJ. One Autopsy Proved Neocortical Lewy Body Disease Without the Involvement of the Olfactory Bulb and Brainstem. J Korean Med Sci. 2022 Jun 3;37(23):e195. doi: 10.3346/jkms.2022.37.e195.